Home/ Peptides/ MOTS-C

MOTS-C

Mitochondrial · Metabolic Subcutaneous Injectable

MOTS-C is a 16-amino-acid peptide unusual for being encoded in the mitochondrial genome itself — not the nuclear DNA. It acts as a metabolic regulator that improves insulin sensitivity, exercise capacity, and the way your mitochondria convert food into usable energy.

Best for: Metabolic dysfunction, exercise performance, insulin resistance, fatigue at the cellular level.

Book Consult→ Get discounts with memberships →
Lab-guided protocolsPersonalized dosingProvider-led oversightIn-clinic & telehealth Lab-guided protocolsPersonalized dosingProvider-led oversightIn-clinic & telehealth
Frequently Asked
What clients want to know about MOTS-C

The questions, answered.

  • Improves insulin sensitivity at the cellular level.
  • Enhances exercise capacity and recovery.
  • Supports mitochondrial biogenesis — more and healthier energy factories.
  • Addresses cellular-level fatigue beyond simple stimulants.
  • May ease weight loss when paired with GLP-1 therapy.
  • Anti-aging signaling at the mitochondrial level.
  • Mitochondrial-derived peptide: encoded in mtDNA, signals across systems.
  • AMPK pathway activation: the master energy-sensing pathway.
  • Improved glucose uptake in muscle.
  • Mitochondrial biogenesis support.
  • Weeks 1–2: Subtle energy lift and improved recovery from workouts.
  • Weeks 4–6: Glucose and insulin markers trend better; exercise capacity rises.
  • Weeks 8–12: Metabolic and energetic gains consolidate; many clients continue at maintenance dose.
  • Mild injection-site reactions.
  • Initial fatigue as mitochondrial machinery upregulates.
  • Headache — rare and short-lived.
  • Pair with strength or zone-2 training for amplified mitochondrial response.
  • Eat enough protein and creatine to fuel the new cellular activity.
  • Stay well hydrated.
  • Reassess insulin/glucose markers at 12 weeks.
  • Active malignancy without provider oversight.
  • Pregnancy or breastfeeding.
  • Known peptide allergy.
Important Note The FDA's position on peptides continues to evolve. Availability of specific compounds may change, and not all peptides discussed are currently offered at every visit. Book a consultation with our provider team to discuss your goals, current options, and what's appropriate for you.
Related Protocols
Often paired or layered alongside MOTS-C

Layered with intention.

Repair & Recovery
BPC-157
Body Protective Compound
Repair & Recovery
TB-500
Thymosin Beta-4 Fragment
Repair & Recovery · Immune
KPV
Alpha-MSH Fragment
— Begin

Precision protocols.
Designed around you.

Every TAI peptide protocol is lab-guided and provider-led. Start with biomarkers, design around your goals, refine at intervals. Available in-clinic and via telehealth.

Book Consult→ Membership pricing →